2. Signaling Pathways
  3. Immunology/Inflammation
  4. Salt-inducible Kinase (SIK)
  5. Salt-inducible Kinase (SIK) Isoform

Salt-inducible Kinase (SIK)

 

Salt-inducible Kinase (SIK) Related Products (10):

Cat. No. Product Name Effect Purity
  • HY-129141
    YKL-06-062
    		Inhibitor 99.40%
    YKL-06-062 is a second-generation salt-inducible kinase (SIK) inhibitor with an IC50 of 2.12 nM/1.40 nM/2.86 nM for SIK1, SIK2 and SIK3, respectively.
  • HY-150203
    GLPG3970
    		Inhibitor 99.64%
    GLPG3970 (compound 88) is a first-in-class SIK2/SIK3 inhibitor. GLPG3970 can be used for the research of inflammation and autoimmune disease.
  • HY-120056
    YKL-06-061
    		Inhibitor 99.21%
    YKL-06-061 is a potent, selective, second-generation salt-inducible kinase (SIK) inhibitor with IC50 values of 6.56 nM/1.77 nM/20.5 nM for SIK1/2/3, respectively.
  • HY-P1576A
    AMARA peptide TFA
    		99.29%
    AMARA peptide (TFA) is a substrate for salt-inducible kinase (SIK) and adenosine monophosphate activated protein kinase (AMPK).
  • HY-138001
    WH-4-025
    		Inhibitor 99.31%
    WH-4-025 is a Salt-inducible kinase (SIK) inhibitor (WO2016023014 A2).
  • HY-120877A
    (R)-MRT199665
    		Inhibitor 98.70%
    (R)-MRT199665 is an isomer of MRT199665 (HY-120877). MRT199665 is a potent and ATP-competitive, selective MARK/SIK/AMPK inhibitor with IC50s of 2/2/3/2 nM, 10/10 nM, and 110/12/43 nM for MARK1/MARK2/MARK3/MARK14, AMPKα1/AMPKα2, and SIK1/SIK2/SIK3, respectively. MRT199665 causes apoptosis in MEF2C-activated human acute myeloid leukemias (AML) cells. MRT199665 inhibits the phosphorylation of SIK substrate CRTC3 at S370.
  • HY-159657
    SIK-IN-4
    		Inhibitor
    SIK-IN-4 (compound 34) is a SIK inhibitor, with IC50 values of 1.2 nM, 0.9 nM and 1.8 nM for SIK1, SIK2 and SIK3, respectively.
  • HY-N1570R
    Pterosin B (Standard)
    		Inhibitor
    Pterosin B (Standard) is the analytical standard of Pterosin B. This product is intended for research and analytical applications. Pterosin B, a indanone found in bracken fern (Pteridium aquilinum), is an inhibitor of salt-inducible kinase 3 (Sik3) signaling. Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3.
  • HY-149365
    SIKs-IN-1
    		Inhibitor
    SIKs-IN-1 (compound 8h), a pyrimidine-5-carboxamide derivative, is a Salt-inducible kinases (SIKs) inhibitor. SIKs regulates the transformation of M1/M2 macrophages, involving in inflammation process. SIKs-IN-1 inhibits SIK activity, up-regulates anti-inflammatory cytokine IL-10, but down-regulates pro-inflammatory cytokine IL-12. SIKs-IN-1 shows excellent anti-inflammatory effects in a DSS-induced colitis model.
  • HY-149075
    MR22
    		Inhibitor
    MR22 is a potent pan-SIK (salt-inducible kinase) inhibitor. MR22 no longer exhibits activity on STE group kinases and displays excellent selectivity in a representative kinase panel. MR22-dependent SIK inhibition led to centrosome dissociation and subsequent cell-cycle arrest in ovarian cancer cells.